About This Event
HMRI Research Seminar Series
Kamrul M. Hasan, PhD
Assistant Professor, Department of Internal Medicine, Charles R. Drew University of Medicine and Science
Wednesday, August 5 | 3–4pm | Zoom & in-person
"CARF (CDKN2AIP) Against Metabolic Dysfunction: From Insulin Resistance to Fatty Liver"
ABOUT THE SPEAKER
Dr. Kamrul M. Hasan is a faculty investigator at Charles R. Drew University of Medicine and Science, where he joined the School of Medicine (Division of Endocrinology, Department of Internal Medicine) in 2015–2016. He earned a B.S. in Biology and an M.S. in Microbiology from the University of Dhaka, Bangladesh, and a Ph.D. in Microbiology, Immunology, and Pathology from the Institute of Medical Science at the University of Tokyo. Following his Ph.D., he completed STA/NEDO postdoctoral training at Japan’s National Institute of Advanced Industrial Science and Technology (AIST) before moving to the City of Hope Beckman Research Institute (2009–2014) as a visiting/staff scientist. Dr. Hasan was among the first to identify and mechanistically characterize CARF (CDKN2AIP) as a p53-interacting regulator, defining a novel node in the ARF–MDM2–p53 tumor suppressor network and linking CARF to transcriptional and RNA-processing control. His laboratory now investigates CARF as a regulator of metabolic dysfunction, with emphasis on insulin resistance and hepatic steatosis/MASLD and progression to NASH. Ongoing projects dissect CARF-dependent regulation of the FOXA2–CPT2 fatty-acid oxidation axis and its integration with nicotine- and diet-induced lipolysis, ER stress, and steatotic remodeling in hepatocyte and mouse models. He also studies CARF-mediated pathways in cancer metabolism, including therapy-induced neuroendocrine differentiation in prostate cancer. Dr. Hasan’s research has been supported by NIH programs (including NIGMS SC2 and SuRE R16 awards), and he has authored more than 40 peer-reviewed publications and a book chapter, while mentoring trainees from high school through postdoctoral levels.
About This Event
HMRI Research Seminar Series
Kamrul M. Hasan, PhD
Assistant Professor, Department of Internal Medicine, Charles R. Drew University of Medicine and Science
Wednesday, August 5 | 3–4pm | Zoom & in-person
"CARF (CDKN2AIP) Against Metabolic Dysfunction: From Insulin Resistance to Fatty Liver"
ABOUT THE SPEAKER
Dr. Kamrul M. Hasan is a faculty investigator at Charles R. Drew University of Medicine and Science, where he joined the School of Medicine (Division of Endocrinology, Department of Internal Medicine) in 2015–2016. He earned a B.S. in Biology and an M.S. in Microbiology from the University of Dhaka, Bangladesh, and a Ph.D. in Microbiology, Immunology, and Pathology from the Institute of Medical Science at the University of Tokyo. Following his Ph.D., he completed STA/NEDO postdoctoral training at Japan’s National Institute of Advanced Industrial Science and Technology (AIST) before moving to the City of Hope Beckman Research Institute (2009–2014) as a visiting/staff scientist. Dr. Hasan was among the first to identify and mechanistically characterize CARF (CDKN2AIP) as a p53-interacting regulator, defining a novel node in the ARF–MDM2–p53 tumor suppressor network and linking CARF to transcriptional and RNA-processing control. His laboratory now investigates CARF as a regulator of metabolic dysfunction, with emphasis on insulin resistance and hepatic steatosis/MASLD and progression to NASH. Ongoing projects dissect CARF-dependent regulation of the FOXA2–CPT2 fatty-acid oxidation axis and its integration with nicotine- and diet-induced lipolysis, ER stress, and steatotic remodeling in hepatocyte and mouse models. He also studies CARF-mediated pathways in cancer metabolism, including therapy-induced neuroendocrine differentiation in prostate cancer. Dr. Hasan’s research has been supported by NIH programs (including NIGMS SC2 and SuRE R16 awards), and he has authored more than 40 peer-reviewed publications and a book chapter, while mentoring trainees from high school through postdoctoral levels.