Program

 9:00 am - 9:15 am: Welcome

• CJD Foundation and Organizing Committee

9:15 am - 10:30 am: Prion transmission and propagation and the potential for transmission of ADRDs

• Moderator: Glenn Telling, PhD, Director, Prion Research Center, Colorado State University, Fort Collins, CO
• Jason Bartz, PhD, Chair and Professor, Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE
• Joaquin Castilla, PhD, IKERBasque Research Professor, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain

10:30 am - 10:45 am: Break

10:45 am - 12:00 pm: One model to rule them all: Prion-like transmission as the ideal neurodegenerative animal model

• Moderator: Joel Watts, PhD, Associate Professor, Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada
• Mathias Jucker, PhD, German Centre for Neurodegenerative Diseases (DZNE) and University of Tübingen, Germany
• Kelvin C. Luk, PhD MTR, Research Associate Professor of Pathology and Laboratory Medicine, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
• Sue-Ann Mok, PhD, Assistant Professor, Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada

12:00 pm - 12:20 pm: Late breaking news talks

• Robert C.C. Mercer, PhD, Boston University 
• Abdullatif Alsulami, PhD, Colorado State University

12:20 pm - 1:30 pm: Lunch

1:30 pm - 2:20 pm: Keynote

• Virtual: Stanley B. Prusiner, MD, Director, Institute for Neurodegenerative Diseases, University of California, San Francisco Weill Institute for Neurosciences, San Francisco, CA

2:20 pm - 3:35 pm: Structural biology of prion proteins and other ADRDs

• Moderator: Byron Caughey, PhD, Rocky Mountain Labs, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT
• Grace Hallinan, PhD, Indiana University School of Medicine, Indianapolis, IN
• Szymon W. Manka, PhD, MRC Prion Unit, Institute of Prion Diseases, UC London, London, England

3:35 pm - 3:55 pm: Break

3:55 pm - 4:55 pm: Genetic aspects of prion disease and other ADRDs

• Moderator: Simon Mead, PhD, Clinical Professor, MRC Prion Unit, Institute of Prion Diseases, UC London, London, England and National Prion Clinic, UC London, London, England
• Eric Minikel, PhD, Senior Group Leader, Broad Institute of MIT and Harvard, Cambridge, MA

4:55 pm - 6:10 pm: Protein aggregation seeding assays: From prions to other ADRD proteinopathies

• Moderator: Claudio Soto, PhD, Director, The George and Cynthia W Mitchell Center for Alzheimer's Disease and Other Brain Related Illnesses, Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX
• Allison Kraus, PhD, Associate Professor, Division of Experimental Pathology, Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH
• Piero Parchi, MD, PhD, Associate Professor, Department of Biomedial and Neuromotor Sciences, University of Bologna, Bologna, Italy

6:10 pm - 6:30 pm: Late breaking news talks

• Jean Royce Gatdula, PhD Student, Boston University
• Thomas Trainer, PhD Student, MRC Prion Unit, Institute of Prion Diseases, UC London

6:30 pm - 8:00 pm: Poster Sessions and Networking with Light Dinner

• Organizing Committee 

9:00 am - 9:15 am: Opening remarks

• Organizing Committee

9:15 am - 10:00am: Keynote

• Michel Goedert, FRS, FMedSci, Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, England

10:00 am - 10:45 am: Panel: Impact of Prion Disease on Caregivers and Those at Risk

• Moderator: Debbie Yobs, President and Executive Director, CJD Foundation
• Families: Trevor Baierl, Nick De Maggio, Pamela Fear, Amanda Kalinsky, Vicki Qualley

10:45 am - 11:00 am: Break

11:00 am - 12:00 pm: Neuropathologic overlap of prion diseases and ADRDs: Potential for cross-seeding

• Moderator: Gabor G. Kovacs MD, PhD, Professor, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
• Bernardino Ghetti, MD, Distinguished Professor, Indiana University School of Medicine, Indianapolis, IN
• Rodrigo Morales, PhD, Professor, The George and Cynthia W Mitchell Center for Alzheimer's Disease and Other Brain Related Illnesses, Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX

12:00 pm - 1:20 pm: Lunch and “Meet the PI”

1:20 pm - 2:20 pm: Clinical diagnostics of prion disease and how they are informing novel ADRD diagnostics

• Moderator: Brian Appleby, MD, Director, National Prion Disease Pathology Surveillance Center, Case Western Reserve U School of Medicine, Cleveland, OH
• Gregory Day, MD, Department of Neurology, Mayo Clinic, Jacksonville, FL
• Richard Knight, BA, BM BCh, FRCP(E), Chair, CJD Support Network, U.K. and Emeritus Professor of Clinical Neurology, The University of Edinburgh, Edinburgh, Scotland

2:20 pm - 3:35 pm: Prion-like phenomena

• Moderator: Amanda L. Woerman, PhD, Associate Professor, Prion Research Center, Department of Microbiology, Immunology, and Pathology, College of Vetrinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO
• Karen Ashe, MD, PhD, Professor, Department of Neurology, University of Minnesota Medical School, Minneapolis, MN, U.S.A.
• Melanie Meyer-Lüehmann, PhD, Professor, Department of Neurology and Neuroscience, University of Freiburg, Freiburg, Germany
• Nathalie Van Den Berge, MScEng, PhD, Associate Professor, Department of Clinical Medicine - Core Centre for Molecular Morphology, Section for Stereology and Microscopy, Aarhus University, Aarhus, Denmark

3:40 pm - 4:00 pm: Break

4:00 pm - 4:30 pm: Late breaking news talks

• Reed Wickner, MD, Section Chief, Genetics of Simple Eukaryotes Section, Laboratory of Biochemistry & Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
• Mahsa Pourhamzeh, PhD, University of California, San Diego
• Dr. Surabhi Mehra, Postdoctoral Fellow at Tanz Centre for Research in Neurodegenerative Diseases

4:30 pm - 5:45 pm: Workshop discussion: How the Prion and AD/ADRD fields can partner to achieve advances in all protein-misfolding diseases

• Moderator: Claudio Soto, PhD, Director, The George and Cynthia W Mitchell Center for Alzheimer's Disease and Other Brain Related Illnesses, Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX
• Moderator: Brian Appleby, MD, Director, National Prion Disease Pathology Surveillance Center, Case Western Reserve U School of Medicine, Cleveland, OH
• John Collinge, CBE, FRS, FMedSci, Director, MRC Prion Unit, Institute of Prion Diseases, UC London, London, England
• Sonia Vallabh, PhD, Senior Group Leader, Broad Institute of MIT and Harvard, Cambridge, MA
• Amanda L. Woerman, PhD, Associate Professor, Prion Research Center, Department of Microbiology, Immunology, and Pathology, College of Vetrinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO
• Jyan Yu Austin Yang, PhD, Program Director, Neurobiology of Aging and Neurodegeneration Branch, Division of Neuroscience, National Institute on Aging, National Institutes of Health

5:45 pm - 7:30 pm: Poster Sessions and Networking/Dinner

• Organizing Committee

9:00 am - 9:15 am: Opening comments

• Organizing Committee

9:15 am - 10:00 am: Keynote

• John Collinge, CBE, FRS, FMedSci, Director, MRC Prion Unit, Institute of Prion Diseases, UC London, London, England

10:00 am - 11:15 am: Prion pathogenesis and toxicity and pathophysiologic mechanisms in ADRDs

• Moderator: Christina Sigurdson, DVM, PhD, Department of Pathology, Microbiology, and Immunology, University of of California, Davis School of Veterinary Medicine, Davis, CA and Sigurdson Lab, Department of Pathology, University of California, San Diego, San Diego, CA
• Adriano Aguzzi, Prof. Dr. med., Director, Institute of Neuropathology, University of Zürich, Zürich, Switzerland
• David Harris, MD, PhD, Department of Biochemistry and Cell Biology, Boston University School of Medicine, Boston, MA

11:15 am - 11:30 am: Break

11:30 am - 12:40 pm: Rational drug design for prion diseases and how this informs other ADRDs

• Moderator: Sonia Vallabh, PhD, Senior Group Leader, Broad Institute of MIT and Harvard, Cambridge, MA
• Ken Chan, PhD, Group Leader, Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA
• Holly Kordasiewicz, PhD, Senior Vice President, Neurology, Ionis Pharmaceuticals, Inc., Carlsbad, CA

12:40 pm - 1:45 pm: Understanding NIH AD/ADRD Programs and Opportunities

• William P. Daley, PhD, Program Director, Neural Environment Cluster, Division of Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health

1:45 pm - 3:00 pm: Networking